What is phase II detox?
Phase II is often called conjugation. Here, enzymes attach a water friendly molecule, such as glutathione, glucuronic acid, an acetyl group, a sulfate or a methyl group, to a compound. This makes it easier to dissolve and remove through bile or urine. Phase II handles hormones, medications, bilirubin and many environmental compounds. It also tidies up the reactive intermediates that Phase I can produce, which is why the two phases work best in balance.
How your genes play a role
Each conjugation route is run by enzymes built from specific genes. Some common variants reduce activity, and a few, such as GSTM1 and GSTT1, can be missing entirely in many healthy people. Others influence acetylation speed or the processing of bilirubin. Your genes describe your starting tendencies, while diet and lifestyle continually shape how these pathways perform.
Phase II is part of how your body keeps a calm internal environment. Understanding your tendencies can add context to how you respond to some medications, how you process hormones and how much you may lean on antioxidant support from food. It can also help explain small everyday differences, such as variations in bilirubin levels. For many people, the most useful takeaway is simply knowing which routes are naturally strong and which may welcome a little more support.
What your report shows
Your Phase II Detox results are explained in plain language in your private EvoDNA account, alongside the other areas in your kit.
- Glutathione pathwaysWhether your glutathione related genes are present and how active they tend to be.
- Acetylation speedWhether your NAT2 profile suggests faster or slower acetylation of certain compounds.
- GlucuronidationHow your UGT genes may influence the handling of bilirubin, hormones and some medications.
- Antioxidant defenseYour tendencies for neutralizing reactive oxygen in the cell's energy centers.
| Gene | What it does | Result |
|---|---|---|
| GSTM1 | Helps attach glutathione to compounds for removal, and is… | Typical |
| GSTT1 | Another glutathione enzyme that some people naturally do not… | Moderate effect |
| NAT2 | Adds acetyl groups to some medications and dietary compounds,… | Typical |
Each result comes with a plain-language explanation and practical points to discuss with your clinician.
Illustration only. Your report reflects your own genetic results.
Genes we analyze
| Gene | Role |
|---|---|
| GSTM1 | Helps attach glutathione to compounds for removal, and is absent in many healthy people. |
| GSTT1 | Another glutathione enzyme that some people naturally do not carry. |
| NAT2 | Adds acetyl groups to some medications and dietary compounds, making people faster or slower acetylators. |
| UGT1A1 | Processes bilirubin, and common variants are linked to mildly higher bilirubin in Gilbert's syndrome. |
| SOD2 | Makes an antioxidant enzyme that neutralizes reactive oxygen inside mitochondria. |
Full panel: 13 genes
GSTM1, GSTT1, GSTP1, GSTA1, NAT1, NAT2, UGT1A1, UGT1A4, UGT1A6, UGT1A9, TPMT, COMT, SOD2
Putting results to use
Many people use their results as a starting point for conversations with their clinician about:
Broccoli and its relatives contain compounds often discussed for supporting Phase II enzymes.
A varied, plant rich plate supplies antioxidants that complement your own defenses.
Water and fiber help carry conjugated compounds out through urine and the gut.
Reducing smoke and charred foods may lighten the load on your clearance pathways.
Questions
What does it mean if I am missing GSTM1 or GSTT1?
It is a common, normal variation. Your body has other glutathione enzymes and routes, and your clinician can help you consider what, if anything, it means for you.
Is Phase II the same as a detox diet?
No. Phase II is a continuous biological process that runs whether or not you follow a particular plan. Everyday nutrition supports it far more than short programs.
Why is COMT in both detox and methylation?
COMT clears certain hormones and messengers by attaching a methyl group. That makes it both a Phase II enzyme and a user of the methylation pathway.
Only interested in this area? The Detox Phase 1 & 2 Genetic Report is available on its own for $99.00.
