What is longevity?
Aging is a gradual process that touches every cell. Over time, cells accumulate small amounts of damage, repair systems work a little harder, and protective structures such as telomeres, the caps at the ends of chromosomes, slowly shorten. How well your body maintains and repairs itself helps shape healthspan, the years spent in good health. Researchers study long-lived families to understand which biological pathways seem to help.
How your genes play a role
Several genes stand out in that research. APOE is one of the most studied genes in brain and heart aging. FOXO3 has been linked to longevity in multiple populations. SIRT1 and SIRT3 relate to cellular maintenance and energy. SOD2, CAT and GPX1 make antioxidant enzymes, and TERC is part of the system that maintains telomeres.
Many of the habits that support healthy aging are simple and familiar. Understanding your genetic tendencies can give those habits a more personal meaning, and help you and your clinician decide where to focus attention over time. Longevity genetics is a story of probabilities, not fate, and much of how you age remains shaped by daily choices, relationships and environment.
What your report shows
Your Longevity results are explained in plain language in your private EvoDNA account, alongside the other areas in your kit.
- Well-studied variantsYour versions of genes such as APOE and FOXO3 that are central to aging research.
- Cellular defensesHow your antioxidant enzyme genes may help protect cells from everyday wear.
- Maintenance pathwaysVariants in genes linked to cellular repair, energy and resilience.
- Telomere biologyGenetic context on the system that helps maintain the ends of your chromosomes.
| Gene | What it does | Result |
|---|---|---|
| APOE | Helps transport fats and cholesterol in the body and… | Typical |
| FOXO3 | Produces a protein that helps cells respond to stress,… | Moderate effect |
| SIRT1 | Makes an enzyme involved in cellular maintenance that responds… | Typical |
Each result comes with a plain-language explanation and practical points to discuss with your clinician.
Illustration only. Your report reflects your own genetic results.
Genes we analyze
| Gene | Role |
|---|---|
| APOE | Helps transport fats and cholesterol in the body and is one of the most studied genes in brain aging. |
| FOXO3 | Produces a protein that helps cells respond to stress, and certain variants are linked to longevity. |
| SIRT1 | Makes an enzyme involved in cellular maintenance that responds to nutrient and energy levels. |
| CAT | Produces catalase, an enzyme that breaks down hydrogen peroxide into water and oxygen. |
| TERC | Provides the RNA template that telomerase uses to rebuild the protective ends of chromosomes. |
Full panel: 11 genes
APOE, FOXO3, SIRT1, SIRT3, SOD2, CAT, GPX1, MTHFR, KLOTHO, TERC, AASS
Putting results to use
Many people use their results as a starting point for conversations with their clinician about:
Regular physical activity is one of the most consistently discussed habits for healthy aging.
A diet rich in plants, fiber and healthy fats is frequently associated with aging well.
Restful sleep supports repair processes throughout the body and brain.
Meaningful relationships and purpose are often highlighted in research on long, healthy lives.
Questions
Can my DNA tell me how long I will live?
No. Lifespan depends on genetics, lifestyle, environment, healthcare and chance. Your report offers context on pathways linked to aging, not a prediction.
Should I be concerned about my APOE result?
APOE is widely studied, and no single version determines your future. If you have questions about your result, your clinician or a genetic counselor can help you understand it in context.
How is this different from an epigenetic age test?
This area looks at the DNA you were born with, which does not change. Epigenetic tests look at chemical marks on your DNA that can shift over time with lifestyle and age.
Only interested in this area? The Longevity Screener is available on its own for $99.00.
