Your HLA genes determine how your immune system recognizes pathogens. Poor immune genetics don’t mean you’re doomed—but you need DIFFERENT strategies than people with strong natural immunity.
HLA, IL6, and TNF genes control how your immune system fights infection and response. FKBP5 methylation shows how well you handle cortisol.
Inflammation is your body’s natural defense. But when it lingers, it becomes silent damage — speeding up aging and increasing your risk for arthritis, diabetes, cardiovascular disease, and dementia.
EvoDNA helps you uncover why your body reacts the way it does, and how to take control.
Infection Defense
Frequent colds, slow recovery, and increased susceptibility to viruses
Energy & Resilience
Low vitality, poor stress tolerance, and burnout
Brain & Mood Health
Immune imbalance impacts focus, mood stability, and mental clarity
Aging & Longevity
Accelerated immune aging weakens protection as you get older
You’re Not Weak—Your Immune Genetics Are Different. You catch every cold. They never get sick. You have seasonal allergies—they don’t. It’s not hygiene. It’s your HLA genes and immune response genetics. Know your vulnerabilities, then strengthen defenses. Your coworker gets exposed to everything—never sick. You wash hands constantly—still catch every bug. It’s not you.
Variants in IL6 and TNF drive excessive cytokine release, while epigenetic shifts from poor diet hyper-methylate anti-inflammatory genes. This test uses GWAS-derived PRS and methylation clocks to quantify your baseline, with evidence showing lifestyle tweaks reduce markers by 25-40%.
– Genetics explain variable responses to stressors, preventing unnecessary meds.
– Epigenetics show how sleep or gut health dials inflammation up/down.
– Proactive steps cut chronic disease risk by 30-50%.
❖ Genetic Advantage: Some people naturally suppress inflammation more easily, thanks to how their IL6 gene is methylated.
❖ Immune System Switches: Histone acetylation acts like a switch, turning immune pathways on or off as needed.
❖ Aging & Lifestyle: “Inflammaging” explains why inflammation increases with age, but your lifestyle choices can help slow this natural process.
Inflammation is both a defense mechanism and a driver of disease. The Inflammation DNA Test integrates genetics and epigenetics to help you:
[Order My Inflammation DNA Test Today]
IL6 & TNF: If you have high-risk genotypes, your body might react with stronger inflammation.
IL10: Lower levels of IL10 mean your body has fewer “brakes” on inflammation.
CRP: This helps explain if your blood tests show higher levels of inflammation.
NFKB1: Genetic changes here can influence your long-term disease risk by affecting your immune system.
Focuses on immune signaling, antioxidant defense, and repair pathways. For instance, TNF rs1800629 boosts pro-inflammatory signals, while SOD2 supports free radical neutralization—insights direct glutathione or curcumin use.
Gene | SNP | Function | Impact | How it Relates to Long Term Disease |
IL6 | rs1800795 | Cytokine production | G allele raises CRP levels | Chronic inflammation in joints/heart |
TNF | rs1800629 | Tumor necrosis factor | Increases NF-κB activity | Amplifies swelling and tissue damage |
SOD2 | rs4880 | Superoxide dismutase | Val variant lowers efficiency | Higher oxidative stress burden |
GPX1 | rs1050450 | Glutathione peroxidase | Pro allele reduces detox | Slower recovery from stressors |
NFKB1 | rs4648068 | Transcription factor for immunity | Influences pathway activation | Modulates overall inflammatory response |
Methylation in AHRR or F2RL3 reflects exposure-driven flares, reversible via habits like yoga or berry-rich diets. Tracks how cumulative stress or toxins shift your “inflammasome” balance.
Your lifestyle choices deeply influence inflammation, even if you have high-risk genes, through epigenetic changes that:
➢ Alter cytokine gene activity
➢ Regulate NF-κB pathway genes
➢ Control immune responses
➢ Drive age-related methylation changes
➢ Reprogram immune genes through exercise & diet
Epigenetic Marker | Mechanism | Impact on Inflammation |
IL6 promoter methylation | Regulates cytokine expression | Hypomethylation leads to sustained flares |
TNF CpG sites | Epigenetic control of necrosis factor | Altered patterns from diet/stress |
SOD2 mitochondrial marks | Oxidative response imprint | Tracks antioxidant needs over time |
NFKB pathway methylation | Immune transcription silencing | Lifestyle influences flare frequency |
AHRR cg05575921 | Toxin exposure signature | Links pollution/smoking to chronic states |
EvoDNA Advantage | Standard Test |
Combines PRS, epigenetics, and actionable plans for full-body inflammation | Limited cytokine panels without lifestyle integration |
Monitors changes with retesting and habit feedback | Static genetic report only |
Does this diagnose conditions like arthritis?
No, it highlights predispositions for early management.
How reversible is inflammation?
Highly—epigenetic shifts from 3-6 months of optimized habits can normalize markers.
Better than blood tests like CRP?
It explains why your CRP is high, guiding long-term fixes.
Who benefits?
Anyone with fatigue, joint pain, or family history of inflammatory diseases.
